Search results for "downstream processing"
Article
QbD and PAT in Upstream and Downstream Processing
DOWNSTREAM PROCESSING
BioPharm: In implementing QbD, what would you identify as the CQAs in a typical downstream bioprocess in which the product was produced using cell culture?
Weber …
Article
Addressing the Complex Nature of Downstream Processing with QbD
Challenges of QbD in downstream processing
With the complex nature of biologics comes more complex quality concerns. Joey Studts, director late-stage downstream development in the bioprocessing d…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
The increasing volumes, cell densities, and protein masses have posed numerous new challenges for downstream processing.
ADDRESSING CHALLENGES IN mAb PROCESSING
Shrinking timelines have neces…
Article
Process Chromatography Selection for Downstream Processing Applications
Selecting the appropriate separation technology plays a big role in maximizing productivity in any downstream processing application. Some factors companies may consider when selecting a separation te…
Article
Downstream Processing Continues to Worry CMOs
Langer
Downstream processing continues to be a significant pain point for contract manufacturing organizations (CMOs), and downstream-fueled bottlenecks don’t appear to show any signs of abating, …
Article
Trends in Downstream Bioprocessing
Downstream processing (DSP) has seen significant challenges over the past few years. Improved upstream bioprocessing has created increasingly higher product titres and resulted in purification bottle …
Article
Downstream Processing for Cell-Based Therapies
…e-scale cell expansion; however, equally important is the development of large-scale harvesting and downstream processing operations. This paper presents and summarizes some of the challenges associa…
Article
Using Single-Use Technologies in Downstream Processing
Mehta states that the use of SUS in downstream processing may “reduce risk of cross contamination and carryover due to inadequate cleaning steps.”
BioPharm International spoke with Nilesh Mehta ab…
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Single-use technology is gaining ground in downstream bioprocessing, but challenges stall further adoption.
By Feliza Mirasol
ARTMOIS/STOCK.ADOBE.COM
Biopharmaceutical manufactu…
Article
SEC in the Modern Downstream Purification Process
Mar 01, 2015
By R. Christopher Manzari, J. Kevin O'Donnell
BioPharm International
Volume 3, Issue 28
Since the introduction of commercial chromatography resins approximately six de…